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According to research, countries with low crime in Latin America include Argentina, Chile, Uruguay and Costa Rica. Venezuela`s pretty harsh on tourists, but gas is super cheap there, so you can rent a car fairly inexpensively. Cuba actually has one of the lowest crime rates in this hemisphere. Guatemala, Colombia, Brazil, Honduras, Venezuela, and the Dominican Republic are all considered pretty unsafe.

Panama is extremely safe, especially considering the terrible roads in other Central and South American countries. Highway safety is a big issue and Panama has the best roads. Places like Costa Rica and Nicaragua pale in comparison.

Panama`s pretty darn safe for tourists, especially along the coastlines. Much of the crime committed is opportunistic. Costa Rica is seeing more and more crime, making Panama seem quite hospitable for expats.